Hibiki Kawamata Fujita, Ph.D.

I have a long-lasting interest in pathogenic mechanisms of ALS, particularly from the angle of mitochondrial involvement (bioenergetic impairments, calcium dysregulation, protein import defects). Genetic mutations in CHCHD10, a mitochondrial protein with still unknown function, is associated with familial ALS and mitochondrial myopathies. CHCHD10 mutations have become a recent focus of our laboratory. I am especially interested in the processes of mutant protein aggregation and its downstream metabolic effects, as well as therapies to tackle these problems through metabolic and pharmaceutical interventions.   

Active Funding:
Muscular Dystrophy Association MDA

Genetic and metabolic strategies for mutant CHCHD10 neuromuscular disorders 


Project ALS/NextGen ALS 2021-01 

Pathogenic mechanisms and therapeutic strategies for CHCHD10 ALS 


Full List of Published Work from My Bibliography:

Weill Cornell Medicine Mitochondria and Neurodegeneration Lab 407 East 61st Street, 5th Floor New York, NY 10065 Phone: (646) 962-8271